ar X iv : 0 70 5 . 40 84 v 1 [ q - bi o . M N ] 2 8 M ay 2 00 7 Comment on “ Regularizing capacity of metabolic networks ”
نویسنده
چکیده
In a recent paper, Marr, Müller-Linow and Hütt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of reference models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr et al. We argue that this issue calls for a more detailed type of modeling.
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